中国广东和浙江地区年轻冠心病患者危险因素的回顾性分析。

Retrospective analysis of risk factors in young patients with coronary artery disease in Guangdong and Zhejiang, China.

作者信息

Fang Chongfeng, Chen Yangxin, Nie Ruqiong, Li Guoqi, Xu Gen, Zhou Shuxian, Wang Jingfeng

机构信息

Department of Cardiology, Taizhou Hospital affiliated to Wenzhou Medical College, Linhai, China.

出版信息

Acta Cardiol. 2009 Apr;64(2):195-9. doi: 10.2143/AC.64.2.2036137.

DOI:10.2143/AC.64.2.2036137

PMID:19476111

Abstract

OBJECTIVES

The objective of this study is to investigate the clustering status of risk factors for young patients with coronary artery disease (CAD) and analyse the relationship between risk factors and CAD.

METHODS

168 patients with CAD aged under 45 years, 170 age-matched non-CAD individuals (angiographically normal) and 170 patients with CAD aged over 45 years were set as CAD group, control group and reference group, respectively. Plasma levels of lipids, C-reactive protein (CRP), traditional risk factors (hypertension, hyperlipidaemia, diabetes, obesity, smoking) were evaluated.

RESULTS

The following results were obtainted: (I) there was a significant difference in gender, proportion of smoking, TC and TG between the CAD group and the control group, and also in gender, smoking, hypertension, diabetes, BMI and blood lipids between the CAD group and the reference group (P < 0.05); (2) there was a significant difference in levels ofTG,TC, HDL-C, LDL-C and BMI (P < 0.05), but no remarkable difference in ApoB/ApoA1 and CRP between the CAD group and the reference group (P > 0.05).There were significant differences in TG, ApoB/ApoA1 and CRP (P < 0.05), but no remarkable difference in other factors between the CAD group and the control group (P > 0.05); (3) logistic regression showed a close relationship between CAD and smoking (OR = 2.5, 95% CI: 1.43-3.98), CRP (OR = 2.71,95% CI: 1.46-5.88),TG (OR = 1.58, 95% CI: 1.25-2.75) and ApoB/ApoA1 (OR = 1.93, 95% CI: 1.14-3.13).

CONCLUSIONS

Smoking, CRP, ApoB/ApoA1 ratio and TG are independent risk factors for young patients with CAD.

摘要

目的

本研究旨在调查年轻冠心病（CAD）患者危险因素的聚集状况，并分析危险因素与CAD之间的关系。

方法

将168例年龄在45岁以下的CAD患者、170例年龄匹配的非CAD个体（血管造影正常）和170例年龄在45岁以上的CAD患者分别设为CAD组、对照组和参照组。评估血脂、C反应蛋白（CRP）、传统危险因素（高血压、高脂血症、糖尿病、肥胖、吸烟）的血浆水平。

结果

获得以下结果：（I）CAD组与对照组在性别、吸烟比例、总胆固醇（TC）和甘油三酯（TG）方面存在显著差异，CAD组与参照组在性别、吸烟、高血压、糖尿病、体重指数（BMI）和血脂方面也存在显著差异（P<0.05）；（2）CAD组与参照组在TG、TC、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和BMI水平上存在显著差异（P<0.05），但载脂蛋白B/载脂蛋白A1（ApoB/ApoA1）和CRP无显著差异（P>0.05）。CAD组与对照组在TG、ApoB/ApoA1和CRP方面存在显著差异（P<0.05），但其他因素无显著差异（P>0.05）；（3）逻辑回归显示CAD与吸烟（比值比[OR]=2.5，95%可信区间[CI]：1.43 - 3.98）、CRP（OR = 2.71，95%CI：1.46 - 5.88）、TG（OR = 1.58，95%CI：1.25 - 2.75）和ApoB/ApoA1（OR = 1.93，95%CI：1.14 - 3.13）密切相关。