Vikram Bhadrasain, Coleman C Norman, Deye James A
Clinical Radiation Oncology Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Rockville, Maryland 20852, USA.
Oncology (Williston Park). 2009 Apr 15;23(4):380-5.
In December 2006, the Radiation Research Program of the Division of Cancer Treatment and Diagnosis of the National Cancer Institute hosted a workshop intended to address current issues related to advanced radiation therapy technologies, with an eye toward (1) defining the specific toxicities that have limited the success of "conventional" radiation therapy, (2) examining the evidence from phase III studies for the improvements attributed to the advanced technologies in the treatment of several cancers commonly treated with radiation therapy, and (3) determining the opportunities and priorities for further technologic development and clinical trials. The new technologies offer substantial theoretical advantage in radiation dose distributions that, if realized in clinical practice, may help many cancer patients live longer and/or better. The precision of the advanced technologies may allow us to reduce the volume of normal tissue irradiated in the vicinity of the clinical target volume. Part 1 of this two-part article, which appeared in the March issue of ONCOLOGY, provided a general overview of the workshop discussion, focusing on the challenges posed by the new technologies and resources available or in development for meeting those challenges. This month, part 2 will outline the state of the science for each disease site.
2006年12月，美国国立癌症研究所癌症治疗与诊断司的放射研究项目举办了一次研讨会，旨在探讨与先进放射治疗技术相关的当前问题，着眼于：（1）确定限制“传统”放射治疗成功的具体毒性；（2）审查III期研究的证据，以了解先进技术在治疗几种常用放射治疗的癌症方面所带来的改善；（3）确定进一步技术开发和临床试验的机会及优先事项。这些新技术在辐射剂量分布方面具有显著的理论优势，如果能在临床实践中实现，可能有助于许多癌症患者延长寿命和/或提高生活质量。先进技术的精确性或许能使我们减少临床靶区附近正常组织的受照体积。这篇分两部分的文章的第一部分发表在《肿瘤学》3月刊上，对研讨会讨论内容进行了总体概述，重点关注新技术带来的挑战以及应对这些挑战可利用的现有或正在开发的资源。本月，第二部分将概述每个疾病部位的科学现状。
