Li Xiao-Nian, Pu Jian-Xin, Du Xue, Yang Liu-Meng, An Hui-Mei, Lei Chun, He Fei, Luo Xiao, Zheng Yong-Tang, Lu Yang, Xiao Wei-Lie, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
J Nat Prod. 2009 Jun;72(6):1133-41. doi: 10.1021/np900123z.
Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.
从中华五味子的地上部分分离得到了14个新的木脂素，铁箍散素A-N（1-14），以及13个已知化合物。通过多种光谱技术结合确定了1-13的结构和绝对构型。化合物14是以外消旋体形式获得的。在评估对HIV-1的抑制活性时，铁箍散素G（7）表现出抗HIV-1活性，其半数有效浓度（EC50）值为7.9微摩尔，治疗指数（TI）大于25。
