一种快速合成9-氮杂双环[3.3.1]壬烷N-氧基（ABNO）的方法：另一种用于醇氧化的高活性有机催化剂。
An expeditious entry to 9-azabicyclo[3.3.1]nonane N-oxyl (ABNO): another highly active organocatalyst for oxidation of alcohols.
作者信息
Shibuya Masatoshi, Tomizawa Masaki, Sasano Yusuke, Iwabuchi Yoshiharu
机构信息
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aobayama, Sendai 980-8578, Japan.
出版信息
J Org Chem. 2009 Jun 19;74(12):4619-22. doi: 10.1021/jo900486w.
PMID:19476345
Abstract
A practical, three-step synthetic route to 9-azabicyclo[3.3.1]nonane N-oxyl (ABNO, 3), an unhindered, stable class of nitroxyl radical, has been developed. ABNO exhibits a highly active nature compared with TEMPO in the catalytic oxidation of alcohols to their corresponding carbonyl compounds.
摘要
已开发出一种实用的三步合成路线来制备9-氮杂双环[3.3.1]壬烷N-氧基（ABNO，3），这是一类空间位阻小、稳定的氮氧自由基。与TEMPO相比，ABNO在将醇催化氧化为相应羰基化合物的过程中表现出高活性。
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