Harrison Odile B, Evans Nicholas J, Blair Jessica M, Grimes Holly S, Tinsley Colin R, Nassif Xavier, Kriz Paula, Ure Roisin, Gray Steve J, Derrick Jeremy P, Maiden Martin C J, Feavers Ian M
Department of Zoology, University of Oxford, Oxford, United Kingdom.
J Infect Dis. 2009 Jul 1;200(1):94-8. doi: 10.1086/599377.
The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.
对疾病分离株和带菌脑膜炎奈瑟菌分离株中的血红蛋白受体基因(hmbR)分布进行了研究,结果显示该基因在疾病分离株中的检出频率显著高于带菌分离株。在没有hmbR的分离株中,该位点被exl2或exl3盒式元件或一个名为exl4的“假hmbR”基因占据。hmbR位点在已公布的脑膜炎奈瑟菌、淋病奈瑟菌和乳酸奈瑟菌序列类型640的基因组中表现出致病岛的特征。这些数据与hmbR基因在脑膜炎球菌病中的作用一致。