血红蛋白受体hmbR在脑膜炎球菌毒力中作用的流行病学证据。
Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence.
作者信息
Harrison Odile B, Evans Nicholas J, Blair Jessica M, Grimes Holly S, Tinsley Colin R, Nassif Xavier, Kriz Paula, Ure Roisin, Gray Steve J, Derrick Jeremy P, Maiden Martin C J, Feavers Ian M
机构信息
Department of Zoology, University of Oxford, Oxford, United Kingdom.
出版信息
J Infect Dis. 2009 Jul 1;200(1):94-8. doi: 10.1086/599377.
Abstract
The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.
摘要
对疾病分离株和带菌脑膜炎奈瑟菌分离株中的血红蛋白受体基因（hmbR）分布进行了研究，结果显示该基因在疾病分离株中的检出频率显著高于带菌分离株。在没有hmbR的分离株中，该位点被exl2或exl3盒式元件或一个名为exl4的“假hmbR”基因占据。hmbR位点在已公布的脑膜炎奈瑟菌、淋病奈瑟菌和乳酸奈瑟菌序列类型640的基因组中表现出致病岛的特征。这些数据与hmbR基因在脑膜炎球菌病中的作用一致。
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本文引用的文献
1
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone.
Genomics. 2008 Jan;91(1):78-87. doi: 10.1016/j.ygeno.2007.10.004. Epub 2007 Nov 26.
2
Pathogenicity islands: a molecular toolbox for bacterial virulence.
Cell Microbiol. 2006 Nov;8(11):1707-19. doi: 10.1111/j.1462-5822.2006.00794.x. Epub 2006 Aug 24.
3
A chromosomally integrated bacteriophage in invasive meningococci.
J Exp Med. 2005 Jun 20;201(12):1905-13. doi: 10.1084/jem.20050112.
4
New Zealand's epidemic of meningococcal disease described using molecular analysis: implications for vaccine delivery.
Vaccine. 2005 Mar 18;23(17-18):2228-30. doi: 10.1016/j.vaccine.2005.01.050.
5
Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway.
J Clin Microbiol. 2004 Nov;42(11):5146-53. doi: 10.1128/JCM.42.11.5146-5153.2004.
6
Distribution of surface protein variants among hyperinvasive meningococci: implications for vaccine design.
Infect Immun. 2004 Oct;72(10):5955-62. doi: 10.1128/IAI.72.10.5955-5962.2004.
7
Comparative genomics identifies the genetic islands that distinguish Neisseria meningitidis, the agent of cerebrospinal meningitis, from other Neisseria species.
Infect Immun. 2002 Dec;70(12):7063-72. doi: 10.1128/IAI.70.12.7063-7072.2002.
8
Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes.
EMBO Rep. 2001 May;2(5):376-81. doi: 10.1093/embo-reports/kve097.
9
exl, an exchangeable genetic island in Neisseria meningitidis.
Infect Immun. 2001 Mar;69(3):1687-96. doi: 10.1128/IAI.69.3.1687-1696.2001.
10
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