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美国外科医师学会国家外科质量改进计划的发展:结直肠手术的发病率和死亡率风险计算器

Development of an American College of Surgeons National Surgery Quality Improvement Program: morbidity and mortality risk calculator for colorectal surgery.

作者信息

Cohen Mark E, Bilimoria Karl Y, Ko Clifford Y, Hall Bruce Lee

机构信息

Division of Research and Optimal Patient Care, American College of Surgeons, Chicago, IL 6061-3211, USA.

出版信息

J Am Coll Surg. 2009 Jun;208(6):1009-16. doi: 10.1016/j.jamcollsurg.2009.01.043. Epub 2009 Apr 17.

Abstract

BACKGROUND

Surgical decision-making and informed patient consent both benefit from having accurate information about risk. But currently available risk estimating systems have one or more limitations associated with lack of specificity to operation type, size of sample (reliability), range of outcomes predicted, and appreciation of hospital effects.

STUDY DESIGN

Data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) patients who underwent colorectal surgery in 2006 to 2007 were used to generate logistic prediction models for 30-day morbidity, serious morbidity, and mortality. Results for these three models were then used to construct a universal multivariable model to predict risk for all three outcomes. Model performance was externally validated against 2005 data.

RESULTS

For 2006 to 2007, 28,863 patients were identified who underwent major colorectal operations at 182 hospitals. A single 15-variable predictor model exhibited discrimination (c-statistic) close to that observed for the separate models on all three outcomes. Similar discrimination was found when the 2006 to 2007 universal model was applied to 3,037 operations conducted in 2005 at 37 hospitals.

CONCLUSIONS

The ACS NSQIP colorectal risk calculator allows surgeons to preoperatively provide patients with detailed information about their personal risks of overall morbidity, serious morbidity, and mortality. Because ACS NSQIP can also categorize hospitals as performing better or worse than expected (or as expected), surgeons have the opportunity to adjust risk probabilities for patients at their institutions accordingly.

摘要

背景

手术决策和患者知情同意都受益于准确的风险信息。但目前可用的风险评估系统存在一个或多个局限性,包括对手术类型缺乏特异性、样本量(可靠性)、预测结果范围以及对医院影响的认识。

研究设计

利用美国外科医师学会国家外科质量改进计划(ACS NSQIP)2006年至2007年接受结直肠手术患者的数据,生成30天发病率、严重发病率和死亡率的逻辑预测模型。然后将这三个模型的结果用于构建一个通用的多变量模型,以预测所有三个结果的风险。模型性能通过2005年的数据进行外部验证。

结果

2006年至2007年,在182家医院中,有28863名患者接受了主要的结直肠手术。一个包含15个变量的单一预测模型在所有三个结果上的辨别力(c统计量)与单独模型相近。当将2006年至2007年的通用模型应用于2005年在37家医院进行的3037例手术时,发现了类似的辨别力。

结论

ACS NSQIP结直肠风险计算器使外科医生能够在术前向患者提供有关其总体发病率、严重发病率和死亡率的个人风险的详细信息。由于ACS NSQIP还可以将医院分类为表现优于预期、差于预期(或符合预期),外科医生有机会相应地调整其所在机构患者的风险概率。

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