Tzounopoulos Thanos, Kraus Nina
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Neuron. 2009 May 28;62(4):463-9. doi: 10.1016/j.neuron.2009.05.002.
Mechanisms of plasticity have traditionally been ascribed to higher-order sensory processing areas such as the cortex, whereas early sensory processing centers have been considered largely hard-wired. In agreement with this view, the auditory brainstem has been viewed as a nonplastic site, important for preserving temporal information and minimizing transmission delays. However, recent groundbreaking results from animal models and human studies have revealed remarkable evidence for cellular and behavioral mechanisms for learning and memory in the auditory brainstem.
传统上，可塑性机制被归因于诸如皮层等高级感觉处理区域，而早期感觉处理中心在很大程度上被认为是固定连接的。与这一观点一致，听觉脑干一直被视为一个无可塑性的部位，对保留时间信息和最小化传输延迟很重要。然而，最近来自动物模型和人体研究的开创性结果揭示了听觉脑干中学习和记忆的细胞及行为机制的显著证据。
