Chandrasekaran Bharath, Skoe Erika, Kraus Nina
Department of Communication Sciences and Disorders, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA,
Brain Topogr. 2014 Jul;27(4):539-52. doi: 10.1007/s10548-013-0323-9. Epub 2013 Oct 23.
In direct conflict with the concept of auditory brainstem nuclei as passive relay stations for behaviorally-relevant signals, recent studies have demonstrated plasticity of the auditory signal in the brainstem. In this paper we provide an overview of the forms of plasticity evidenced in subcortical auditory regions. We posit an integrative model of auditory plasticity, which argues for a continuous, online modulation of bottom-up signals via corticofugal pathways, based on an algorithm that anticipates and updates incoming stimulus regularities. We discuss the negative implications of plasticity in clinical dysfunction and propose novel methods of eliciting brainstem responses that could specify the biological nature of auditory processing deficits.
最近的研究表明脑干中听觉信号具有可塑性，这与将听觉脑干核视为行为相关信号的被动中继站的概念直接冲突。在本文中，我们概述了在皮层下听觉区域所证实的可塑性形式。我们提出了一种听觉可塑性的整合模型，该模型基于一种预测和更新传入刺激规律的算法，主张通过皮质离心通路对自下而上的信号进行连续的在线调制。我们讨论了可塑性在临床功能障碍中的负面影响，并提出了引发脑干反应的新方法，这些方法可以明确听觉处理缺陷的生物学本质。
