自分泌运动因子和溶血磷脂酸受体的表达会增加乳腺肿瘤发生、侵袭及转移。
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
作者信息
Liu Shuying, Umezu-Goto Makiko, Murph Mandi, Lu Yiling, Liu Wenbin, Zhang Fan, Yu Shuangxing, Stephens L Clifton, Cui Xiaojiang, Murrow George, Coombes Kevin, Muller William, Hung Mien-Chie, Perou Charles M, Lee Adrian V, Fang Xianjun, Mills Gordon B
机构信息
Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Cancer Cell. 2009 Jun 2;15(6):539-50. doi: 10.1016/j.ccr.2009.03.027.
Abstract
Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
摘要
溶血磷脂酸（LPA）通过高亲和力G蛋白偶联受体发挥作用，介导与肿瘤发生相关的大量生理和病理活动。LPA受体和自分泌运动因子（ATX/LysoPLD）是产生LPA的主要酶，在多种癌症谱系中异常表达。然而，ATX和LPA受体在乳腺癌发生和发展中的作用尚未得到评估。我们证明，在转基因小鼠的乳腺上皮中，ATX或每个edg家族LPA受体的表达足以诱导高频率的迟发性、雌激素受体（ER）阳性、侵袭性和转移性乳腺癌。因此，ATX和LPA受体可促进乳腺癌的发生和发展。
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