• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
ATX-LPA receptor axis in inflammation and cancer.ATX-LPA 受体轴在炎症和癌症中的作用。
Cell Cycle. 2009 Nov 15;8(22):3695-701. doi: 10.4161/cc.8.22.9937. Epub 2009 Nov 27.
2
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.自分泌运动因子和溶血磷脂酸受体的表达会增加乳腺肿瘤发生、侵袭及转移。
Cancer Cell. 2009 Jun 2;15(6):539-50. doi: 10.1016/j.ccr.2009.03.027.
3
Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.自分泌酶受 TSA 通过抑制 HDAC3 和 HDAC7 诱导，并拮抗 TSA 诱导的细胞凋亡。
Mol Cancer. 2011 Feb 12;10:18. doi: 10.1186/1476-4598-10-18.
4
Regulation and biological activities of the autotaxin-LPA axis.自分泌运动因子-溶血磷脂酸轴的调节及生物学活性
Prog Lipid Res. 2007 Mar;46(2):145-60. doi: 10.1016/j.plipres.2007.02.001. Epub 2007 Mar 16.
5
Requirement of Osteopontin in the migration and protection against Taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells.骨桥蛋白在SGC7901细胞中通过自分泌运动因子-溶血磷脂酸轴迁移及抵抗紫杉醇诱导的细胞凋亡中的作用
BMC Cell Biol. 2011 Mar 16;12:11. doi: 10.1186/1471-2121-12-11.
6
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.溶血磷脂酸生成酶自分泌运动因子参与淋巴细胞与内皮细胞的相互作用。
Am J Pathol. 2008 Nov;173(5):1566-76. doi: 10.2353/ajpath.2008.071153. Epub 2008 Sep 25.
7
Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration.自分泌酶通过溶血磷脂酸受体信号转导促进血管内皮生长因子诱导的内皮细胞迁移。
Mol Cancer Res. 2010 Mar;8(3):309-21. doi: 10.1158/1541-7786.MCR-09-0288. Epub 2010 Mar 2.
8
Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.溶血磷脂酸的产生和作用：乳腺癌起始和进展中的关键新角色。
Br J Cancer. 2010 Mar 16;102(6):941-6. doi: 10.1038/sj.bjc.6605588.
9
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.自分泌运动因子，一种分泌型溶血磷脂酶D，在发育过程中对血管形成至关重要。
Mol Cell Biol. 2006 Jul;26(13):5015-22. doi: 10.1128/MCB.02419-05.
10
ATX-LPA axis induces expression of OPN in hepatic cancer cell SMMC7721.ATX-LPA 轴诱导肝癌细胞 SMMC7721 中 OPN 的表达。
Anat Rec (Hoboken). 2011 Mar;294(3):406-11. doi: 10.1002/ar.21324. Epub 2010 Dec 31.

引用本文的文献

1
Synthesis of Autotaxin-Inhibiting Lipid Nanoparticles to Regulate Autophagy and Inflammatory Responses in Activated Macrophages.合成自分泌运动因子抑制性脂质纳米颗粒以调节活化巨噬细胞中的自噬和炎症反应。
Tissue Eng Regen Med. 2025 Feb 25. doi: 10.1007/s13770-025-00705-0.
2
Novel Autotaxin Inhibitor ATX-1d Significantly Enhances Potency of Paclitaxel-An In Silico and In Vitro Study.新型 Autotaxin 抑制剂 ATX-1d 显著增强紫杉醇的效力：一项计算机模拟和体外研究。
Molecules. 2024 Sep 10;29(18):4285. doi: 10.3390/molecules29184285.
3
Infliximab, a Monoclonal Antibody against TNF-α, Inhibits NF-κB Activation, Autotaxin Expression and Breast Cancer Metastasis to Lungs.英夫利昔单抗，一种抗TNF-α单克隆抗体，可抑制NF-κB激活、自分泌运动因子表达及乳腺癌肺转移。
Cancers (Basel). 2023 Dec 21;16(1):52. doi: 10.3390/cancers16010052.
4
Revealing the Preventable Effects of Fu-Zheng-Qu-Xie Decoction against Recurrence and Metastasis of Postoperative Early-Stage Lung Adenocarcinoma Based on Network Pharmacology Coupled with Metabolomics Analysis.基于网络药理学与代谢组学分析揭示扶正祛邪方对早期肺腺癌术后复发和转移的可预防作用
ACS Omega. 2023 Sep 20;8(39):35555-35570. doi: 10.1021/acsomega.3c00122. eCollection 2023 Oct 3.
5
Autotaxin production in the human breast cancer tumor microenvironment mitigates tumor progression in early breast cancers.人乳腺癌肿瘤微环境中自分泌运动因子的产生可减轻早期乳腺癌的肿瘤进展。
Am J Cancer Res. 2023 Jul 15;13(7):2790-2813. eCollection 2023.
6
EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer.EMT 通过激活胞吐 Rabs 来协调肺癌的侵袭和免疫抑制。
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2220276120. doi: 10.1073/pnas.2220276120. Epub 2023 Jul 5.
7
Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28.含油酸的磷脂酰肌醇是SPG28的血液生物标志物候选物。
Biomedicines. 2023 Apr 4;11(4):1092. doi: 10.3390/biomedicines11041092.
8
Circulating autotaxin levels in healthy teenagers: Data from the Vitados cohort.健康青少年的循环自分泌运动因子水平：来自Vitados队列的数据。
Front Pediatr. 2023 Feb 13;11:1094705. doi: 10.3389/fped.2023.1094705. eCollection 2023.
9
Identification of Prognostic Markers of DNA Damage and Oxidative Stress in Diagnosing Papillary Renal Cell Carcinoma Based on High-Throughput Bioinformatics Screening.基于高通量生物信息学筛选鉴定诊断乳头状肾细胞癌中DNA损伤和氧化应激的预后标志物
J Oncol. 2023 Feb 4;2023:4640563. doi: 10.1155/2023/4640563. eCollection 2023.
10
The Autotaxin-LPA Axis Emerges as a Novel Regulator of Smooth Muscle Cell Phenotypic Modulation during Intimal Hyperplasia.Autotaxin-LPA 轴在血管内膜增生过程中作为平滑肌细胞表型调节的新调节因子出现。
Int J Mol Sci. 2023 Feb 2;24(3):2913. doi: 10.3390/ijms24032913.

本文引用的文献

1
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.自分泌运动因子和溶血磷脂酸受体的表达会增加乳腺肿瘤发生、侵袭及转移。
Cancer Cell. 2009 Jun 2;15(6):539-50. doi: 10.1016/j.ccr.2009.03.027.
2
Cancer statistics, 2009.2009年癌症统计数据。
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49. doi: 10.3322/caac.20006. Epub 2009 May 27.
3
Molecular targets for treatment of inflammatory breast cancer.炎性乳腺癌治疗的分子靶点
Nat Rev Clin Oncol. 2009 Jul;6(7):387-94. doi: 10.1038/nrclinonc.2009.73. Epub 2009 May 26.
4
The biology of ovarian cancer: new opportunities for translation.卵巢癌生物学：转化医学的新机遇
Nat Rev Cancer. 2009 Jun;9(6):415-28. doi: 10.1038/nrc2644.
5
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.溶血磷脂酸诱导的转录谱代表浆液性上皮性卵巢癌且预后较差。
PLoS One. 2009;4(5):e5583. doi: 10.1371/journal.pone.0005583. Epub 2009 May 15.
6
Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.一种新型溶血磷脂酸受体p2y5/LPA6的鉴定与特性分析
J Biol Chem. 2009 Jun 26;284(26):17731-41. doi: 10.1074/jbc.M808506200. Epub 2009 Apr 22.
7
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.在结肠炎相关癌症的实验模型中，LPA2的缺失会减弱肿瘤形成。
Gastroenterology. 2009 May;136(5):1711-20. doi: 10.1053/j.gastro.2009.01.002. Epub 2009 Jan 9.
8
Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells.酰基甘油激酶在溶血磷脂酸诱导人支气管上皮细胞分泌白细胞介素-8及表皮生长因子受体反式激活中的作用
Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L328-36. doi: 10.1152/ajplung.90431.2008. Epub 2008 Dec 26.
9
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.溶血磷脂酸受体决定卵巢癌细胞的致瘤性和侵袭性。
J Natl Cancer Inst. 2008 Nov 19;100(22):1630-42. doi: 10.1093/jnci/djn378. Epub 2008 Nov 11.
10
Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion.鉴定抑制黑色素瘤细胞迁移和侵袭的自分泌运动因子小分子抑制剂。
Mol Cancer Ther. 2008 Oct;7(10):3352-62. doi: 10.1158/1535-7163.MCT-08-0463.

ATX-LPA 受体轴在炎症和癌症中的作用。

ATX-LPA receptor axis in inflammation and cancer.

机构信息

Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

出版信息

Cell Cycle. 2009 Nov 15;8(22):3695-701. doi: 10.4161/cc.8.22.9937. Epub 2009 Nov 27.

DOI:10.4161/cc.8.22.9937
PMID:19855166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4166520/
Abstract

Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G protein-coupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.

摘要

溶血磷脂酸（LPA，1-或 2-酰基-sn-甘油 3-磷酸）通过与一系列高亲和力 G 蛋白偶联受体（GPCR）相互作用，介导多种生理和病理活性。LPA 受体家族成员和自分泌运动因子（ATX/LysoPLD），即主要的 LPA 产生酶，在许多人类乳腺癌和其他几种癌症谱系中异常表达。使用表达 LPA 受体或 ATX 的转基因小鼠，我们最近证明 ATX-LPA 受体轴在乳腺癌发生和癌症相关炎症中起因果作用，进一步验证了 ATX-LPA 受体轴作为癌症的一个丰富治疗靶点。