通过溶血磷脂酸受体信号传导的乳腺肿瘤发生
Mammary tumorigenesis through LPA receptor signaling.
作者信息
Jonkers Jos, Moolenaar Wouter H
机构信息
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
出版信息
Cancer Cell. 2009 Jun 2;15(6):457-9. doi: 10.1016/j.ccr.2009.05.003.
PMID:19477423
Abstract
Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.
摘要
溶血磷脂酸（LPA）是一种脂质生长因子，由一种名为自分泌运动因子（ATX）的细胞外磷脂酶产生，并通过G蛋白偶联受体发挥作用。在本期《癌细胞》杂志中，刘等人表明，ATX或LPA受体的转基因过表达会导致侵袭性和转移性乳腺癌。
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