伯氏疏螺旋体的遗传学
Genetics of Borrelia burgdorferi.
作者信息
Bergström S, Barbour A G, Garon C F, Hindersson P, Saint Girons I, Schwan T G
机构信息
Department of Microbiology, University of Umeå, Sweden.
出版信息
Scand J Infect Dis Suppl. 1991;77:102-7.
Structural analysis by electronmicroscopy and pulsed field agarose gel electrophoresis of the genome of Borrelia burgdorferi has revealed a 1000 kilobase (kb) chromosome and a unique type of extra chromosomal linear DNA, as well as supercoiled circular DNA. The plasmid DNA ranged in size from 1.5 to 50 kb. Gene mapping of the ospA and ospB genes have placed them on the 49 kb linear plasmid molecule. The osp operon of B. burgdorferi has been extensively characterized at the molecular level.
通过电子显微镜和脉冲场琼脂糖凝胶电泳对伯氏疏螺旋体基因组进行的结构分析显示，其具有一条1000千碱基（kb）的染色体、一种独特类型的染色体外线性DNA以及超螺旋环状DNA。质粒DNA的大小范围为1.5至50 kb。ospA和ospB基因的基因图谱已将它们定位在49 kb的线性质粒分子上。伯氏疏螺旋体的osp操纵子已在分子水平上得到广泛表征。
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