Murphy Susannah E, Norbury Raymond, O'Sullivan Ursula, Cowen Philip J, Harmer Catherine J
Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX.
Br J Psychiatry. 2009 Jun;194(6):535-40. doi: 10.1192/bjp.bp.108.056093.
Selective serotonin reuptake inhibitors (SSRIs) are typically thought to have a delay of several weeks in the onset of their clinical effects. However, recent reports suggest they may have a much earlier therapeutic onset. A reduction in amygdala responsivity has been implicated in the therapeutic action of SSRIs.
To investigate the effect of a single dose of an SSRI on the amygdala response to emotional faces.
Twenty-six healthy volunteers were randomised to receive a single oral dose of citalopram (20 mg) or placebo. Effects on the processing of facial expressions were assessed 3 h later using functional magnetic resonance imaging.
Volunteers treated with citalopram displayed a significantly reduced amygdala response to fearful facial expressions compared with placebo.
Such an immediate effect of an SSRI on amygdala responses to threat supports the idea that antidepressants have an earlier onset of therapeutically relevant effects than conventionally thought.
选择性5-羟色胺再摄取抑制剂（SSRIs）通常被认为在临床起效方面会有几周的延迟。然而，最近的报告表明它们可能有更早的治疗起效时间。杏仁核反应性降低与SSRIs的治疗作用有关。
研究单剂量SSRI对杏仁核对情绪面孔反应的影响。
26名健康志愿者被随机分为两组，分别接受单剂量口服西酞普兰（20毫克）或安慰剂。3小时后使用功能磁共振成像评估对面部表情处理的影响。
与安慰剂相比，接受西酞普兰治疗的志愿者对恐惧面部表情的杏仁核反应显著降低。
SSRI对杏仁核对威胁的反应有如此即时的效果，支持了抗抑郁药的治疗相关效果起效时间比传统认为的更早这一观点。
