Omiya Kazuto, Akashi Yoshihiro J, Yoneyama Kihei, Osada Naohiko, Tanabe Kazuhiko, Miyake Fumihiko
Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Int J Sport Nutr Exerc Metab. 2009 Apr;19(2):127-35. doi: 10.1123/ijsnem.19.2.127.
The aim of this study was to clarify the mechanism of impaired exercise tolerance in chronic sleep-restricted conditions by investigating variables related to heart-rate (HR) response to sympathetic nervous stimulation. Sixteen healthy men (mean age 21.5 years) were tested in a control state, acute sleep-loss state, and chronic sleep-restricted state. Participants underwent cardiopulmonary exercise testing in each state. Their norepinephrine (NE) concentration was measured before and immediately after exercise. Intracellular magnesium (Mg) concentration was measured in a resting state. Exercise duration was shorter and the ratio of HR response to the percentage increase in NE was higher in the chronic sleep-restricted state than in the control state. Intracellular Mg gradually decreased from control to chronic sleep restriction. There was a negative correlation between peak exercise duration and the ratios of HR response to the rate of increase in NE. Intracellular Mg was positively correlated with the ratios of HR response to the increase in NE both in control and in acute sleep loss. The authors conclude that the impaired exercise tolerance in a chronic sleep-restricted state is caused by hypersensitivity of the HR response to sympathetic nervous stimulation, which showed a compensation for decreased intracellular Mg concentration.
本研究的目的是通过调查与交感神经刺激引起的心率（HR）反应相关的变量，阐明慢性睡眠受限条件下运动耐力受损的机制。16名健康男性（平均年龄21.5岁）在对照状态、急性睡眠缺失状态和慢性睡眠受限状态下接受测试。参与者在每种状态下都进行了心肺运动测试。在运动前和运动后即刻测量他们的去甲肾上腺素（NE）浓度。在静息状态下测量细胞内镁（Mg）浓度。与对照状态相比，慢性睡眠受限状态下运动持续时间更短，HR反应与NE百分比增加的比值更高。从对照到慢性睡眠受限，细胞内Mg逐渐降低。运动峰值持续时间与HR反应与NE增加率的比值之间存在负相关。在对照和急性睡眠缺失状态下，细胞内Mg与HR反应与NE增加的比值均呈正相关。作者得出结论，慢性睡眠受限状态下运动耐力受损是由HR对交感神经刺激的超敏反应引起的，这表现为对细胞内Mg浓度降低的一种代偿。
