Su Ho-Ming, Lin Tsung-Hsien, Lee Chee-Siong, Lee Hsiang-Chun, Chu Chun-Yuan, Hsu Po-Chao, Voon Wen-Chol, Lai Wen-Ter, Sheu Sheng-Hsiung
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Am J Hypertens. 2009 Aug;22(8):871-6. doi: 10.1038/ajh.2009.94. Epub 2009 May 28.
Right brachial pre-ejection period (rbPEP), brachial-ankle pulse wave velocity (baPWV), and right brachial ejection time (rbET) can be automatically determined from an ABI-form device. The aims of this study are to test the applicability of baPWV-derived myocardial performance index (MPI) (defined as the ratio of rbPEP divided by its own s.d. + baPWV divided by its own s.d. to rbET divided by its own s.d.) as an indicator of combined left ventricular (LV) systolic and diastolic functions.
A sum of 215 patients were consecutively included. The rbPEP, baPWV, and rbET were measured using an ABI-form device and LV function was determined by echocardiography.
After a multivariate analysis, diastolic blood pressure (beta = 0.220, P < 0.001), LV ejection fraction (LVEF) (beta = -0.291, P < 0.001), transmitral E wave velocity (E) (beta = -0.106, P = 0.032), early diastolic mitral annular velocity (Ea) (beta = -0.142, P = 0.009), and ET obtained by tissue Doppler echocardiography (beta = -0.397, P < 0.001) were the major determinants of baPWV-derived MPI. The area under the curve for rbPEP, baPWV, rbET, rbPEP/rbET, and baPWV-derived MPI in prediction of Ea <8 cm/s, E/Ea >10, or LVEF <50% were 0.69, 0.76, 0.67, 0.73, and 0.83, respectively.
BaPWV-derived MPI had a significant correlation with echocardiographic LV diastolic and systolic function. It may be a novel and feasible indicator in assessment of global LV function.
右肱动脉射血前期（rbPEP）、臂踝脉搏波速度（baPWV）和右肱动脉射血时间（rbET）可通过一种类似踝臂指数（ABI）的设备自动测定。本研究的目的是测试基于baPWV的心肌性能指数（MPI）（定义为rbPEP除以其自身标准差加上baPWV除以其自身标准差再除以rbET除以其自身标准差的比值）作为左心室（LV）收缩和舒张功能综合指标的适用性。
连续纳入215例患者。使用类似ABI的设备测量rbPEP、baPWV和rbET，并通过超声心动图测定左心室功能。
多因素分析后，舒张压（β = 0.220，P < 0.001）、左心室射血分数（LVEF）（β = -0.291，P < 0.001）、二尖瓣E峰速度（E）（β = -0.106，P = 0.032）、舒张早期二尖瓣环速度（Ea）（β = -0.142，P = 0.009）以及组织多普勒超声心动图测得的ET（β = -0.397，P < 0.001）是基于baPWV的MPI的主要决定因素。rbPEP、baPWV、rbET、rbPEP/rbET和基于baPWV的MPI预测Ea <8 cm/s、E/Ea >10或LVEF <50%的曲线下面积分别为0.69、0.76、0.67、0.73和0.83。
基于baPWV的MPI与超声心动图测得的左心室舒张和收缩功能显著相关。它可能是评估左心室整体功能的一种新颖且可行的指标。
