Green Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India.
Beilstein J Org Chem. 2009 Mar 25;5:10. doi: 10.3762/bjoc.5.10.
The N-acylation of ethanolamine (2) with various fatty acids 1a-d and esters of fatty acids 1e-h using Candida antarctica B lipase (Novozym((R)) 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.
描述了用南极假丝酵母脂肪酶(Novozym(R)435)对乙醇胺(2)与各种脂肪酸 1a-d 和脂肪酸酯 1e-h 的 N-酰化作用,并讨论了选择性 N-酰化而不是 O-酰化的最佳条件。考察了微波辅助溶液相、固载相和常规方法,比较了结果。酶催化和微波辐射之间存在协同作用。