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使用尿素作为氮源，以硝酸镁或咪唑为催化剂，从非活化羧酸直接合成酰胺。

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO) or imidazole as catalysts.

作者信息

Chhatwal A Rosie, Lomax Helen V, Blacker A John, Williams Jonathan M J, Marcé Patricia

机构信息

Department of Chemistry , University of Bath , Claverton Down , Bath , BA2 7AY , UK . Email:

Centre for Sustainable Chemical Technologies , University of Bath , Claverton Down , Bath , BA2 7AY , UK.

出版信息

Chem Sci. 2020 May 19;11(22):5808-5818. doi: 10.1039/d0sc01317j. eCollection 2020 Jun 14.

DOI:10.1039/d0sc01317j
PMID:32832055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7416778/
Abstract

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO)·6HO or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

摘要

描述了一种从羧酸直接合成伯酰胺和仲酰胺的新方法，该方法使用Mg(NO)·6HO或咪唑作为低成本且易于获得的催化剂，尿素作为稳定且易于操作的氮源。这种方法对于直接合成伯酰胺和甲基酰胺特别有用，避免了使用难以操作的氨气和甲胺气体。此外，该转化不需要使用通常所需的偶联剂或活化剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/06c11afa45f1/d0sc01317j-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/dee1c13b7bd1/d0sc01317j-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/3745b076ccf1/d0sc01317j-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/1c75809f266a/d0sc01317j-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/06c11afa45f1/d0sc01317j-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/dee1c13b7bd1/d0sc01317j-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/3745b076ccf1/d0sc01317j-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/1c75809f266a/d0sc01317j-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32ea/7416778/06c11afa45f1/d0sc01317j-s4.jpg

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