Department of Pediatrics, American Family Children's Hospital, University of Wisconsin, Madison, WI 53792, USA.
Rev Endocr Metab Disord. 2009 Sep;10(3):189-96. doi: 10.1007/s11154-009-9109-5.
An increasingly pervasive environment of reduced activity and easy access to high caloric food is leading to an epidemic of poor cardiovascular fitness, obesity, insulin resistance and type 2 diabetes (T2DM) in children. Studies have shown that insulin resistance (IR) to be an independent predictor for morbidity as well as mortality. These serve as a strong stimulus for public health strategies to improve fitness in children and adolescents. Methods to assess IR, improve IR and understand complications are increasingly important in children.
活动减少和高热量食物易获取的环境日益普遍,导致儿童心血管健康不良、肥胖、胰岛素抵抗和 2 型糖尿病(T2DM)流行。研究表明,胰岛素抵抗(IR)是发病率和死亡率的独立预测因素。这些为改善儿童和青少年健康的公共卫生策略提供了强有力的刺激。评估 IR、改善 IR 和了解并发症的方法在儿童中变得越来越重要。