Margolis P, Driks A, Losick R
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.
Science. 1991 Oct 25;254(5031):562-5. doi: 10.1126/science.1948031.
Early in the process of spore formation in Bacillus subtilis a septum is formed that partitions the sporangium into daughter cells called the forespore and the mother cell. The daughter cells each have their own chromosome but follow dissimilar programs of gene expression. Differential gene expression in the forespore is now shown to be established by the compartmentalized activity of the transcription factor sigma F. The sigma F factor is produced prior to septation, but is active only in the forespore compartment of the post-septation sporangium. The sigma F factor is controlled by the products of sporulation operons spoIIA and spoIIE, which may be responsible for confining its activity to one of the daughter cells.
在枯草芽孢杆菌形成孢子的早期过程中，会形成一个隔膜，将孢子囊分隔成两个子细胞，即前芽孢和母细胞。每个子细胞都有自己的染色体，但遵循不同的基因表达程序。现在表明，前芽孢中的差异基因表达是由转录因子σF的区室化活性建立的。σF因子在隔膜形成之前产生，但仅在后隔膜孢子囊的前芽孢区室中具有活性。σF因子受孢子形成操纵子spoIIA和spoIIE产物的控制，这可能负责将其活性限制在其中一个子细胞中。
