一种观点：宏转录组学作为发现新型生物催化剂的工具。
A perspective: metatranscriptomics as a tool for the discovery of novel biocatalysts.
作者信息
Warnecke Falk, Hess Matthias
机构信息
DOE Joint Genome Institute, Microbial Ecology Program, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
出版信息
J Biotechnol. 2009 Jun 1;142(1):91-5. doi: 10.1016/j.jbiotec.2009.03.022. Epub 2009 Apr 9.
In this mini-review, advantages and current bottlenecks of metatranscriptomic-sequencing for the discovery of novel enzymes for biotechnological applications will be discussed. Comparison of this innovative approach to traditional metagenomic-sequencing will illustrate that expression profiling has a promising future as a direct and very efficient method for the discovery of novel biocatalysts, even from complex microbial communities.
在本综述中，将讨论宏转录组测序在发现用于生物技术应用的新型酶方面的优势和当前存在的瓶颈。将这种创新方法与传统宏基因组测序进行比较，将表明表达谱分析作为一种直接且非常有效的发现新型生物催化剂的方法，即使是从复杂的微生物群落中发现，也具有广阔的前景。
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