Perez Ruiz F, Orte Martinez F J, Zea Mendoza A C, Ruiz del Arbol L, Moreno Caparros A
Division of Rheumatology, Hospital Ramon y Cajal, Madrid, Spain.
Semin Arthritis Rheum. 1991 Aug;21(1):47-54. doi: 10.1016/0049-0172(91)90056-6.
Nodular regenerative hyperplasia (NRH) of the liver is an uncommon pathologic finding associated, in most cases, with rheumatic and hematologic diseases. Although its pathogenesis remains unclear, NRH probably results from liver regeneration to maintain its functional capacity after ischemia-induced injury. An intrahepatic microvascular occlusive mechanism has been considered most likely pathogenetically. NRH may lead to portal hypertension. Thus, the diagnosis of Felty's syndrome must be considered with caution in patients with rheumatoid arthritis (RA) and NRH of the liver. We report seven additional cases of NRH in patients with rheumatic disorders and review the literature to determine the patterns of clinical presentation and natural history of this condition. We also report four patients (three systemic lupus erythematosus [SLE] and one primary antiphospholipid syndrome [PAPS]) in whom antiphospholipid antibodies may have played a role in the genesis of NRH.
肝脏结节性再生性增生（NRH）是一种罕见的病理表现，在大多数情况下与风湿性和血液系统疾病相关。尽管其发病机制尚不清楚，但NRH可能是肝脏在缺血性损伤后为维持其功能能力而进行再生的结果。肝内微血管闭塞机制被认为最有可能是其发病原因。NRH可能导致门静脉高压。因此，对于患有类风湿关节炎（RA）和肝脏NRH的患者，必须谨慎考虑费尔蒂综合征的诊断。我们报告了另外7例风湿性疾病患者的NRH病例，并回顾文献以确定这种疾病的临床表现模式和自然病史。我们还报告了4例患者（3例系统性红斑狼疮[SLE]和1例原发性抗磷脂综合征[PAPS]），其中抗磷脂抗体可能在NRH的发生中起作用。
