Pearce A K, Humphrey T C
Cell Cycle Laboratory, MRC Radiation and Genome Stability Unit, Harwell, OX11 0RD, Didcot, UK.
Trends Cell Biol. 2001 Oct;11(10):426-33. doi: 10.1016/s0962-8924(01)02119-5.
The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.
DNA完整性检查点和应激激酶（SAPK/JNK和p38）通路在调节细胞周期、凋亡以及对应激的转录反应中发挥作用。尽管最初认为它们独立发挥作用，但最近的研究进展表明应激反应通路和检查点通路之间存在诸多联系。在此，我们探讨应激反应通路与检查点通路之间的关系，以及它们如何相互作用来调节细胞周期控制。
