Wang Hao, Wu Ting, Yan Ming, Liu Ge, Li Ping, Zhang Xiao-Qi, Ye Wen-Cai, Zhang Lu-Yong
Key Laboratory of Modern Chinese Medicine, China Pharmceutical University, Nanjing 210009, P. R. China.
Chem Pharm Bull (Tokyo). 2009 Jun;57(6):597-9. doi: 10.1248/cpb.57.597.
One new guaiane-type sesquiterpene glycoside, 2'-O-E-caffeoyl-8alpha-hydroxy-11alpha,13-dihydro-3beta-O-beta-D-glucozaluzanin C (1), was isolated from the whole herb of Ainsliaea fragrans (Compositae), together with five known sesquiterpene lactones: 8alpha-hydroxy-11alpha,13-dihydro-3beta-O-beta-D-glucozaluzanin C (2), 8alpha-hydroxy-11alpha,13-dihydrozaluzanin C (3), 3alpha-hydroxy-11beta,13-dihydro-8alpha-O-beta-D-glucozaluzanin C (4), 3beta-hydroxy-11beta,13-dihydro-8alpha-O-beta-D-glucozaluzanin C (5), 3beta-O-beta-D-glucozaluzanin C (6). The structures of isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. All isolates obtained in the present study were evaluated for their inhibitory effects against cyclooxygenases-1 and 2 in vitro, and the structure-activity relationships were also discussed.
从菊科植物杏香兔儿风的全草中分离得到一个新的愈创木烷型倍半萜糖苷，2'-O-E-咖啡酰基-8α-羟基-11α,13-二氢-3β-O-β-D-葡萄糖基卢扎宁C（1），以及五个已知的倍半萜内酯：8α-羟基-11α,13-二氢-3β-O-β-D-葡萄糖基卢扎宁C（2）、8α-羟基-11α,13-二氢卢扎宁C（3）、3α-羟基-11β,13-二氢-8α-O-β-D-葡萄糖基卢扎宁C（4）、3β-羟基-11β,13-二氢-8α-O-β-D-葡萄糖基卢扎宁C（5）、3β-O-β-D-葡萄糖基卢扎宁C（6）。通过一维和二维核磁共振光谱以及化学方法确定了分离得到的化合物的结构。对本研究中获得的所有分离物进行了体外对环氧化酶-1和2的抑制作用评估，并讨论了构效关系。
