Yakura Takayuki, Omoto Masanori
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan.
Chem Pharm Bull (Tokyo). 2009 Jun;57(6):643-5. doi: 10.1248/cpb.57.643.
Efficient synthesis of p-quinols (2) using catalytic hypervalent iodine oxidation of 4-arylphenols (1) with 4-iodophenoxyacetic acid (3) and Oxone was developed. Reaction of 1 with a catalytic amount of 3 in the presence of Oxone as a co-oxidant in tetrahydrofuran or 1,4-dioxane-water gave the corresponding 2 in excellent yields.
开发了一种利用4-碘苯氧基乙酸（3）和过氧单硫酸盐对4-芳基苯酚（1）进行催化高价碘氧化高效合成对苯二酚（2）的方法。在四氢呋喃或1,4-二氧六环-水体系中，以过氧单硫酸盐作为共氧化剂，1与催化量的3反应，能以优异的产率得到相应的2。
