Thorley J D, Smith J W, Luby J P, Sanford J P
Infect Immun. 1977 Apr;16(1):110-4. doi: 10.1128/iai.16.1.110-114.1977.
The response of subpopulations of peripheral venous blood lymphocytes to systemic bacterial or viral infections was studied. B-lymphocytes were defined by the presence of surface binding sites for mu chains, which were determined by immunofluorescent staining. T-lymphocytes were defined by the ability to form active sheep cell rosettes. Virus-infectible lymphocytes, which may represent activated T-lymphocytes, were defined by the ability to support virus replication. Patients with bacterial infections had an increase in the B-lymphocytes of peripheral venous blood, whereas patients with viral infections had an increase in T-lymphocytes as compared to controls. The number of virus-infectible lymphocytes was increased in patients with bacterial infections but not in patients with viral infections. These studies suggest that subpopulations of human peripheral blood lymphocytes vary in response to different types of infectious agents.
研究了外周静脉血淋巴细胞亚群对全身性细菌或病毒感染的反应。通过免疫荧光染色确定表面存在μ链结合位点来定义B淋巴细胞。通过形成活性绵羊红细胞花环的能力来定义T淋巴细胞。可被病毒感染的淋巴细胞可能代表活化的T淋巴细胞，通过支持病毒复制的能力来定义。与对照组相比，细菌感染患者外周静脉血中的B淋巴细胞增加，而病毒感染患者的T淋巴细胞增加。细菌感染患者中可被病毒感染的淋巴细胞数量增加，而病毒感染患者中则没有增加。这些研究表明，人类外周血淋巴细胞亚群对不同类型的感染因子的反应有所不同。
