Al-Waili N S, Butler G J, Lee B Y, Carrey Z, Petrillo R
Life Support Technology Groups, Chronic Wound Care and Hyperbaric Center, Mount Vernon Hospital, Sound Shore Health System, Westchester, New York, USA.
J Med Eng Technol. 2009;33(7):507-15. doi: 10.1080/03091900701249554.
The purpose of this report is to explore possible therapeutic use of hyperbaric oxygen (HBO(2)) technology on renal and urogenital diseases. HBO(2) reduces inflammation, immunity and inflammatory cytokines, stimulates wound repair and angioneogenesis, maintains tissue oxygenation, increases antioxidant enzymes and heals tissue hypoxia and radionecrosis. A literature review of peer-reviewed articles that address HBO(2), genitourological diseases, renal disease, and dialysis was performed. The paper reviews complications of renal diseases, dialysis, clinical applications of HBO(2), and effect of HBO(2) on renal and urogenital diseases. HBO(2) was used successfully to treat calcific uraemic arteriolopathy, and in many cases of acute renal failure. This technique is particularly useful in the treatment of intractable haemorrhagic cystitis secondary to pelvic radiation therapy and Fournier's gangrene. Clearly HBO(2) might play a role in the management of urogenital diseases, urinary bladder dysfunction and diseases, testicular pathology, renal diseases, and post-traumatic ischaemic injury and/or impaired wound healing and infections. The possible role of HBO(2) for autoimmune diseases, uraemic osteodystrophy or neuropathy due to chronic renal diseases is discussed. The clinical application of this technology is expanding and the various biological influences of HBO(2) encourage testing its possible benefit in renal and urological diseases.
本报告的目的是探讨高压氧（HBO₂）技术在肾脏和泌尿生殖系统疾病中的潜在治疗用途。HBO₂可减轻炎症、免疫反应和炎性细胞因子，刺激伤口修复和血管生成，维持组织氧合，增加抗氧化酶，并治愈组织缺氧和放射性坏死。我们对已发表的关于HBO₂、泌尿生殖系统疾病、肾脏疾病和透析的同行评审文章进行了文献综述。本文回顾了肾脏疾病、透析的并发症，HBO₂的临床应用，以及HBO₂对肾脏和泌尿生殖系统疾病的影响。HBO₂已成功用于治疗钙化性尿毒症小动脉病以及许多急性肾衰竭病例。该技术在治疗盆腔放射治疗后继发的顽固性出血性膀胱炎和福尼尔坏疽方面特别有用。显然，HBO₂可能在泌尿生殖系统疾病、膀胱功能障碍和疾病、睾丸病理学、肾脏疾病以及创伤后缺血性损伤和/或伤口愈合受损及感染的管理中发挥作用。本文还讨论了HBO₂在自身免疫性疾病、慢性肾脏疾病所致的尿毒症性骨营养不良或神经病变中的可能作用。这项技术的临床应用正在不断扩展，HBO₂的各种生物学影响促使人们测试其在肾脏和泌尿系统疾病中的潜在益处。
