Department of Periodontics, Chang-Gung Memorial Hospital, Taipei, Taiwan.
Head Neck. 2010 Jan;32(1):18-25. doi: 10.1002/hed.21138.
Infiltrating macrophage count (IMC) is found to correlate with the progression and prognosis of many human cancers.
This study used immunohistochemistry to measure the IMC (macrophages/high-power field [HPF]) in 92 specimens of oral squamous cell carcinoma (OSCC).
A significantly increased IMC was found in OSCCs with larger tumor size, positive lymph node metastasis, more advanced clinical stages, or recurrence (all ps < .05). Kaplan-Meier survival analysis found that OSCC patients with IMC >196 macrophages/HPF had a significantly shorter disease-free (p = .001, log-rank test) or overall survival (p < .001, log-rank test) than OSCC patients with IMC <196 macrophages/HPF. Multivariate Cox regression analyses showed that IMC >196 macrophages/HPF was an independent predictor for poor disease-free (p = .005) and overall survival of patients with OSCC (p = .015).
The IMC can predict the progression and prognosis of OSCCs in Taiwan.
浸润性巨噬细胞计数（IMC）与许多人类癌症的进展和预后相关。
本研究使用免疫组织化学方法测量了 92 例口腔鳞状细胞癌（OSCC）标本中的 IMC（巨噬细胞/高倍视野 [HPF]）。
在肿瘤较大、淋巴结转移阳性、临床分期较高或复发的 OSCC 中，IMC 显著增加（均 p <.05）。Kaplan-Meier 生存分析发现，IMC >196 个巨噬细胞/HPF 的 OSCC 患者无病生存率（p =.001，对数秩检验）或总生存率（p <.001，对数秩检验）显著短于 IMC <196 个巨噬细胞/HPF 的 OSCC 患者。多变量 Cox 回归分析显示，IMC >196 个巨噬细胞/HPF 是 OSCC 患者无病生存率（p =.005）和总生存率（p =.015）不良的独立预测因素。
IMC 可预测台湾 OSCC 的进展和预后。
