Department of Psychiatry, Ludwig-Maximilian- University, Munich, Germany.
Acta Psychiatr Scand. 2009 Dec;120(6):474-80. doi: 10.1111/j.1600-0447.2009.01412.x. Epub 2009 May 21.
The study aimed to increase the knowledge about the detailed course differences between different forms of bipolar disorder.
Using the prospective life-chart-clinician version, we compared the fine-grain analysis of mood swings and treatment modalities of 18 bipolar II with 31 bipolar I patients.
During an observational period of a mean of 26 months we observed an increase of euthymic days, and a decrease of (sub)depressive and (hypo)manic days. Days in a (sub)depressed state were more frequent than days of (hypo)mania as well as days of subdepression or hypomania in comparison to days of full-blown depression or mania. Bipolar II patients showed an increase in hypomanic days receiving more frequently antidepressants. Bipolar I patients, with a decrease of manic days, were significantly taking more often mood stabilizers.
Treatment in a specialized bipolar clinic improves the overall outcome, but bipolar II disorder seems to be still treated sub-optimally with a possible iatrogenic increase of hypomanic days.
本研究旨在增进对不同形式双相情感障碍详细病程差异的了解。
采用前瞻性生活图表-临床医生版，我们比较了 18 例双相情感障碍 2 型和 31 例双相情感障碍 1 型患者的情绪波动和治疗方式的精细分析。
在平均 26 个月的观察期内，我们观察到心境稳定的天数增加，（亚）抑郁和（轻）躁狂天数减少。处于（亚）抑郁状态的天数比（轻）躁狂天数以及亚抑郁或轻躁狂天数比全面抑郁或躁狂天数更为频繁。接受抗抑郁药治疗的双相情感障碍 2 型患者轻躁狂天数增加。躁狂天数减少的双相情感障碍 1 型患者则更频繁地使用心境稳定剂。
在专门的双相情感障碍诊所进行治疗可改善整体预后，但双相情感障碍 2 型似乎仍未得到最佳治疗，可能导致轻躁狂天数增加。
