Porter Richard J, Moot Will, Inder Maree L, Crowe Marie T, Douglas Katie M, Carter Janet D, Frampton Christopher
Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand.
Specialist Mental Health Services, Te Whatu Ora, Christchurch 8025, New Zealand.
Brain Sci. 2022 Dec 15;12(12):1717. doi: 10.3390/brainsci12121717.
The long-term burden of symptoms is an important outcome in bipolar disorder (BD). A method which has minimal burden of assessment uses a retrospective interview, the Longitudinal Interval Follow-up Examination (LIFE), although this may be subject to problems with recall. This study examines the relationship between the retrospective LIFE scale and concurrently-rated mood rating scales in two clinical trials of 18 months of psychotherapy for patients with BD. The Montgomery-Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were administered every eight to nine weeks and the LIFE was carried out every 6 months. Correlations between scores on mood rating scales and at equivalent times on the LIFE were examined, as well as of potential clinical moderators. There were significant correlations between LIFE depression ratings and concurrent MADRS score (r = 0.57) and between LIFE mania ratings and YMRS score (r = 0.40). In determining "mild depression" on the MADRS, a receiver operating characteristics (ROC) analysis showed an AUC of 0.78 for LIFE scores. Correlations, particularly for depression scores, were high even when the LIFE rating was several months before the interview, suggesting that the LIFE has validity in examining the burden of mood symptoms over time, with relatively little burden of assessment. Future research should examine the relationship between symptom burden and quality of life measured in this way.
症状的长期负担是双相情感障碍（BD）的一项重要预后指标。一种评估负担最小的方法是采用回顾性访谈，即纵向间隔随访检查（LIFE），不过这可能存在回忆方面的问题。本研究在两项针对BD患者的为期18个月心理治疗的临床试验中，考察了回顾性LIFE量表与同期评定的情绪评定量表之间的关系。每八到九周进行一次蒙哥马利-阿斯伯格抑郁评定量表（MADRS）和杨氏躁狂评定量表（YMRS）评定，每6个月进行一次LIFE评定。考察了情绪评定量表得分与LIFE量表在同等时间的得分之间的相关性，以及潜在的临床调节因素。LIFE抑郁评定与同期MADRS得分之间存在显著相关性（r = 0.57），LIFE躁狂评定与YMRS得分之间也存在显著相关性（r = 0.40）。在通过MADRS确定“轻度抑郁”时，一项受试者工作特征（ROC）分析显示LIFE得分的曲线下面积（AUC）为0.78。即使LIFE评定时间比访谈时间早几个月，相关性，尤其是抑郁得分的相关性仍然很高，这表明LIFE在考察情绪症状随时间的负担方面具有有效性，且评估负担相对较小。未来的研究应考察以此方式测量的症状负担与生活质量之间的关系。
