Department of Dermatology, Tri-Service General Hospital, Taipei, Taiwan.
Clin Exp Dermatol. 2009 Dec;34(8):e590-3. doi: 10.1111/j.1365-2230.2009.03261.x. Epub 2009 May 22.
A 43-year-old Taiwanese man who had oculocutaneous albinism type 1 presented with a tumorous lesion over the pubic region. Within the tumour, there was a small pinkish plaque. Histopathologically, the tumour revealed benign naevus cells in the upper dermis and atypical malignant tumour cells in the deeper dermis. Immunohistochemistry using HMB-45 showed intensive positive staining in the deeper dermal tumour cells. Amelanotic malignant melanoma (MM) originating from a pre-existing intradermal naevus was diagnosed.
一位 43 岁的台湾男性，患有眼皮肤白化病 1 型，于会阴部出现肿瘤样病变。肿瘤内有一小片粉红色斑块。组织病理学检查显示，肿瘤在上真皮层呈现良性痣细胞，在更深的真皮层呈现非典型恶性肿瘤细胞。使用 HMB-45 的免疫组织化学染色显示，深层真皮肿瘤细胞呈强阳性染色。诊断为源于原有真皮痣的无色素恶性黑色素瘤（MM）。
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