Ratner M Ia, Brodskiĭ M A, Zubkin M L, Stenina I I, Slutskin I M
Ter Arkh. 1991;63(6):12-5.
Tubulointerstitial alterations associated with chronic glomerulonephritis (CGN) are definitely dependent on the clinical type of CGN and are accompanied by a decrease of homeostatic functions (the rate of glomerular filtration, osmotic concentration and dilution of urine, hydruresis, the magnitude of CH2O, excretion of ammonium and hydrogen ions, the ratio of ammonium excretion to hydrogen ion excretion). Maximal osmotic concentration and ammonium excretion show an especially considerable decrease. The clinical type permitting one to diagnose rather than to reject the presence of alterations and the status of certain tubular functions, osmotic concentration in particular and, to a less degree, ammonium excretion, permitting to reject the presence of the tubulointerstitial component (TIC) are of known but restricted importance for TIC recognition. The TIC can be diagnosed more adequately in exploring definite pairs of renal functions, particularly osmotic concentration of urine and ammonium excretion and maximal hydruresis and excretion of hydrogen ions. This approach is both helpful in confirming and rejecting the presence of the TIC. Of special value is the combined assessment of the clinical type and maximal osmotic urine concentration data.
与慢性肾小球肾炎（CGN）相关的肾小管间质改变肯定取决于CGN的临床类型，并伴有稳态功能的下降（肾小球滤过率、尿液的渗透浓度和稀释、水利尿、CH2O量、铵和氢离子排泄、铵排泄与氢离子排泄的比值）。最大渗透浓度和铵排泄尤其显著下降。允许诊断而非排除改变的存在以及某些肾小管功能状态（特别是渗透浓度，其次是铵排泄）的临床类型，对于肾小管间质成分（TIC）的识别虽已知但重要性有限。在探究特定的肾功能对时，特别是尿液的渗透浓度和铵排泄以及最大水利尿和氢离子排泄，能更充分地诊断TIC。这种方法有助于确认和排除TIC的存在。临床类型和最大尿液渗透浓度数据的联合评估具有特殊价值。
