奥美拉唑的特定治疗方案会影响幽门螺杆菌的定位。
Specific therapeutic schemes of omeprazole affect the orientation of Helicobacter pylori.
作者信息
Azevedo-Vethacke Marina, Garten Désirée, Groll Claudia, Schreiber Sören
机构信息
Institut für Physiologie, Ruhr-Universität Bochum, Im Lottental 36, 44801 Bochum, Germany.
出版信息
Antimicrob Agents Chemother. 2009 Aug;53(8):3511-4. doi: 10.1128/AAC.00158-09. Epub 2009 Jun 1.
Abstract
Until now, it has been unclear how proton pump inhibitors (PPIs) support Helicobacter pylori therapy. We tested whether the PPI omeprazole acts on the spatial orientation of H. pylori in the gastric mucus of infected Mongolian gerbils. Following repetitive PPI administration once daily but not following single doses or administration every 8 h, the bacterial spatial distribution changed, indicating a loss of orientation. Therefore, the therapeutic scheme of PPI administration may affect efficiency of treatment.
摘要
到目前为止，尚不清楚质子泵抑制剂（PPIs）如何辅助幽门螺杆菌治疗。我们测试了质子泵抑制剂奥美拉唑是否对感染蒙古沙鼠胃黏液中幽门螺杆菌的空间取向产生作用。每日重复给予质子泵抑制剂，但单次给药或每8小时给药则不会出现这种情况，之后细菌的空间分布发生了变化，表明取向丧失。因此，质子泵抑制剂的给药治疗方案可能会影响治疗效果。
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