血糖控制不佳是2型糖尿病患者高密度脂蛋白胆固醇水平低的独立危险因素。
Poor glycemic control is an independent risk factor for low HDL cholesterol in patients with type 2 diabetes.
作者信息
Gatti Alessandra, Maranghi Marianna, Bacci Simonetta, Carallo Claudio, Gnasso Agostino, Mandosi Elisabetta, Fallarino Mara, Morano Susanna, Trischitta Vincenzo, Filetti Sebastiano
机构信息
Department of Clinical Sciences, Sapienza University of Rome, Rome, Italy.
出版信息
Diabetes Care. 2009 Aug;32(8):1550-2. doi: 10.2337/dc09-0256. Epub 2009 Jun 1.
Abstract
OBJECTIVE To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1-1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1-1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05-1.18], P = 0.00017). CONCLUSIONS Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes.
摘要
目的 确定在2型糖尿病中观察到的血糖控制不佳与低高密度脂蛋白胆固醇之间的关联是否取决于肥胖和/或高甘油三酯血症。研究设计与方法 我们对意大利三个糖尿病中心招募的1819例2型糖尿病且甘油三酯<400mg/dl的患者进行了横断面研究。将低高密度脂蛋白胆固醇的风险作为糖化血红蛋白（A1C）水平的函数进行分析。在对混杂因素进行调整后计算比值比（OR）。结果 A1C每增加1%，低高密度脂蛋白胆固醇的风险显著增加（OR 1.17[95%CI 1.1 - 1.2]，P = 0.00072）；当模型中纳入年龄、性别、吸烟和降脂治疗时未观察到变化（1.17[1.1 - 1.2]，P = 0.00044）。在多变量分析中对肥胖和高甘油三酯血症进行调整后，该关联仍然很强（1.12[1.05 - 1.18]，P = 0.00017）。结论 血糖控制不佳似乎是2型糖尿病患者低高密度脂蛋白胆固醇的独立危险因素。
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