Yangco Bienvenido G, Sher Gulab, Bardin Matthew C
Infectious Disease Research Institute, Advanced Care Hospitalists, Tampa, FL, USA.
South Med J. 2009 Jul;102(7):746-7. doi: 10.1097/SMJ.0b013e3181a82bbb.
Nitazoxanide has been proven to be efficacious for the treatment of Clostridium difficile infection (CDI), but data is limited in peritoneal dialysis (PD) patients. This report details the successful utilization of nitazoxanide and probiotics to treat multirecurrent CDI in a PD patient. A 58-year-old woman was admitted with hypotension, nausea and vomiting attributed to metronidazole therapy for CDI, her third CDI treatment regimen in 3 months. During her admission, the patient developed CDI and was started on a 6-week regimen of nitazoxanide and probiotics to assist in re-establishing the colonic flora. The regimen was well tolerated and the patient remained disease free at follow up, four months later.
硝唑尼特已被证明对治疗艰难梭菌感染（CDI）有效，但在腹膜透析（PD）患者中的数据有限。本报告详细介绍了硝唑尼特和益生菌成功用于治疗一名PD患者的多次复发性CDI的情况。一名58岁女性因甲硝唑治疗CDI出现低血压、恶心和呕吐入院，这是她3个月内的第三次CDI治疗方案。住院期间，该患者发生CDI，并开始接受为期6周的硝唑尼特和益生菌治疗方案，以帮助重建结肠菌群。该方案耐受性良好，4个月后的随访中患者未再发病。
