Bao Haigang, Zhao Chunjiang, Zhang Lifan, Li Junying, Wu Changxin
College of Animal Science and Technology, China Agricultural University, Beijing, PR China.
Mitochondrial DNA. 2008 Oct;19(5):461-4. doi: 10.1080/19401730802449212.
Cytochrome c oxidase (COX) plays important roles in oxidative phosphorylation regulation and oxygen sensing transfer. In the present study, single-nucleotide polymorphisms (SNPs) in three mitochondrially coded subunit genes of COX were identified with the technique of single-strand conformation polymorphism in Tibet Chicken and four lowland chicken breeds-Dongxiang Chicken, Silky Chicken, Hubbard ISA White broiler, and Leghorn layer. In total, 14 SNPs were identified in the three genes of COX of the five chicken breeds, and 13 haplotypes were defined for the 14 SNPs. This work will afford reference for the further study on the association of COX with the adaptation to hypoxia.
细胞色素c氧化酶（COX）在氧化磷酸化调节和氧传感传递中发挥着重要作用。在本研究中，利用单链构象多态性技术，在藏鸡以及四个低地鸡品种——东乡鸡、丝羽乌骨鸡、哈伯德ISA白肉鸡和来航蛋鸡的细胞色素c氧化酶三个线粒体编码亚基基因中鉴定了单核苷酸多态性（SNP）。在这五个鸡品种的细胞色素c氧化酶三个基因中总共鉴定出14个SNP，并为这14个SNP定义了13种单倍型。本研究将为进一步研究细胞色素c氧化酶与低氧适应性之间的关联提供参考。
