Koch M, Mostert J, Heerings M, Uyttenboogaart M, De Keyser J
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Eur J Neurol. 2009 Mar;16(3):348-52. doi: 10.1111/j.1468-1331.2008.02432.x.
To investigate the influence of disability and the speed of disability accumulation on fatigue and depression in a large cohort of patients with multiple sclerosis (MS).
A total of 412 patients completed the Fatigue Severity Scale (FSS) and Center for Epidemiological Studies Depression Scale (CESD). The patients were registered at our outpatient department and demographic and disease specific data were compared between patients with and without severe fatigue (FSS > or = 5.0) and clinically significant depressive symptoms (CESD > or = 16). We investigated the association of Expanded Disability Status Scale (EDSS) scores, multiple sclerosis severity scores (MSSS) and either CESD scores or FSS-scores with severe fatigue and clinically significant depressive symptoms in a multivariable logistic regression model, with adjustment for possible confounders.
Only CESD scores were independently associated with severe fatigue. FSS scores and female gender were independently associated with clinically significant depressive symptoms. Neither EDSS nor MSSS scores were independently associated with fatigue or depression.
In patients with MS, fatigue and depression are strongly associated with each other but not with the degree of disability or the speed of disability accumulation.
在一大群多发性硬化症(MS)患者中,研究残疾及残疾累积速度对疲劳和抑郁的影响。
共有412名患者完成了疲劳严重程度量表(FSS)和流行病学研究中心抑郁量表(CESD)。这些患者在我们的门诊部登记,比较了有和没有严重疲劳(FSS≥5.0)以及有临床显著抑郁症状(CESD≥16)的患者的人口统计学和疾病特异性数据。我们在多变量逻辑回归模型中研究了扩展残疾状态量表(EDSS)评分、多发性硬化症严重程度评分(MSSS)以及CESD评分或FSS评分与严重疲劳和临床显著抑郁症状之间的关联,并对可能的混杂因素进行了调整。
只有CESD评分与严重疲劳独立相关。FSS评分和女性性别与临床显著抑郁症状独立相关。EDSS和MSSS评分均与疲劳或抑郁无独立关联。
在MS患者中,疲劳和抑郁彼此密切相关,但与残疾程度或残疾累积速度无关。