Kale N, Agaoglu J, Tanik O
Department of Neurology, Mayo Clinic College of Medicine, 200 First St. SW, 55905 Rochester, MN, USA.
Neurol Res. 2010 Mar;32(2):221-3. doi: 10.1179/174313209X455664. Epub 2009 Aug 5.
Fatigue is one of the most common disabling symptoms in multiple sclerosis (MS) with significant impact on daily life. The aim of this study is to explore the association among MS fatigue, clinical disability and depression. Fifty-seven patients were assessed by fatigue severity scale (FSS), expanded disability status scale (EDSS) and Beck depression inventory (BDI). Mean FSS score was 4.1 +/- 1.6. Based on FSS scores, patients were divided into three groups: Patients with FSS score >5 (n=10, 32%) were evaluated to present with fatigue symptoms, patients with borderline fatigue (n=29, 50%) had an FSS score between 4 and 5 and patients with no fatigue (n=18, 18%) had an FSS<4. When the patients were compared according to the presence of fatigue symptoms, patients with fatigue had significantly higher EDSS scores (p=0.03). BDI evaluation revealed that 33 (57%) patients had a score > or =11. MS patients with fatigue showed significantly higher BDI scores when compared to patients without fatigue (p=0.0002). A significant relationship among fatigue, disease disability and depression was observed in our study, implying the complex interplay of fatigue and depression with disability.
疲劳是多发性硬化症（MS）中最常见的致残症状之一，对日常生活有重大影响。本研究的目的是探讨MS疲劳、临床残疾和抑郁之间的关联。通过疲劳严重程度量表（FSS）、扩展残疾状态量表（EDSS）和贝克抑郁量表（BDI）对57例患者进行了评估。FSS平均得分为4.1 +/- 1.6。根据FSS评分，患者被分为三组：FSS评分>5的患者（n = 10，32%）被评估为有疲劳症状，临界疲劳患者（n = 29，50%）的FSS评分为4至5，无疲劳患者（n = 18，18%）的FSS<4。当根据疲劳症状的有无对患者进行比较时，有疲劳的患者EDSS评分显著更高（p = 0.03）。BDI评估显示，33例（57%）患者的评分>或=11。与无疲劳的患者相比，有疲劳的MS患者BDI评分显著更高（p = 0.0002）。在我们的研究中观察到疲劳、疾病残疾和抑郁之间存在显著关系，这意味着疲劳和抑郁与残疾之间存在复杂的相互作用。
