Department of Neurology, Brain and Spinal Injury Research Center, MS Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Disabil Rehabil. 2013 Aug;35(18):1509-12. doi: 10.3109/09638288.2012.742575. Epub 2012 Dec 14.
To determine the validity and reliability of the Persian version of the Modified Fatigue Impact Scale (MFIS) questionnaire for Iranian patients with multiple sclerosis (MS).
One hundred and twenty patients with MS and 75 age-matched healthy controls were enrolled. Participants were asked to answer the valid and reliable Persian version of the Beck depression inventory (BDI), Fatigue Severity Scale (FSS) and translated MFIS questionnaires. Twenty cases filed the questionnaire two weeks later to assess reliability. The intra-class correlation coefficient (ICC), Cronbach's alpha and multiple regression analysis were used.
The total MFIS score and subscale scores differed significantly between the patients with MS and the healthy controls. The ICCs and Cronbach's alpha values were also outstandingly high. There was a significant correlation between the FSS and MFIS scores in patients (r = 0.69, p < 0.001). Also, a significant correlation was investigated between the scores of the BDI and the MFIS (r = 0.68, p < 0.001). Multiple linear regression analysis between the MFIS as a dependent variable and Expanded Disability Status Scale (EDSS), BDI and disease duration as independent variables showed that the BDI and EDSS are dependent predictors of the MFIS.
The results of this study indicate that the Persian version of MFIS can be regarded as a valid and reliable scale for assessing fatigue in Iranian patients with MS.
Fatigue is one of the most common, disabling and troublesome complaints of individuals with MS. Different factors such as depression and physical disability are considered to play an important role in MS-related fatigue. Fatigue evaluation by means of a valid and reliable instrument is important in individuals with MS. Persian version of MFIS provides a valid and reliable instrument for fatigue evaluation.
确定经改良后的疲劳影响量表（MFIS）波斯语版本在伊朗多发性硬化症（MS）患者中的有效性和可靠性。
共纳入 120 名 MS 患者和 75 名年龄匹配的健康对照者。要求参与者回答经过验证且可靠的贝克抑郁量表（BDI）、疲劳严重程度量表（FSS）和翻译后的 MFIS 问卷。20 例患者在两周后填写问卷以评估可靠性。使用组内相关系数（ICC）、克朗巴赫α和多元回归分析。
MS 患者与健康对照组之间的 MFIS 总分和子量表评分差异显著。ICC 和克朗巴赫α值也非常高。在患者中，FSS 与 MFIS 评分之间存在显著相关性（r=0.69，p<0.001）。此外，BDI 评分与 MFIS 之间也存在显著相关性（r=0.68，p<0.001）。将 MFIS 作为因变量，扩展残疾状况量表（EDSS）、BDI 和疾病持续时间作为自变量进行多元线性回归分析，结果表明 BDI 和 EDSS 是 MFIS 的依赖性预测因子。
本研究结果表明，MFIS 波斯语版本可作为评估伊朗 MS 患者疲劳的有效且可靠的量表。
疲劳是多发性硬化症患者最常见、最具致残性和最麻烦的症状之一。抑郁和身体残疾等不同因素被认为在 MS 相关疲劳中起着重要作用。使用有效且可靠的工具评估疲劳对 MS 患者很重要。MFIS 波斯语版本为疲劳评估提供了有效且可靠的工具。
