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CTLA4 +49 A/G基因多态性与葡萄牙人群1型糖尿病易感性无关。

The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.

作者信息

Lemos M C, Coutinho E, Gomes L, Bastos M, Fagulha A, Barros L, Carrilho F, Geraldes E, Regateiro F J, Carvalheiro M

机构信息

Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.

出版信息

Int J Immunogenet. 2009 Jun;36(3):193-5. doi: 10.1111/j.1744-313X.2009.00844.x.

DOI:10.1111/j.1744-313X.2009.00844.x
PMID:19490216
Abstract

CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.

摘要

细胞毒性T淋巴细胞相关抗原4（CTLA4）基因多态性与1型糖尿病有关。我们对207例患者和249例对照进行了基因分型，检测CTLA4基因最常研究的多态性（+49A/G（rs231775））。未观察到显著差异，这表明该多态性与葡萄牙人群中的1型糖尿病没有强关联。

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