土耳其儿童中CTLA-4（+49A/G）基因多态性与1型糖尿病
CTLA-4 (+49A/G) polymorphism and type-1 diabetes in Turkish children.
作者信息
Çelmeli Fatih, Türkkahraman Doğa, Özel Deniz, Akçurin Sema, Yegin Olcay
机构信息
Antalya Antalya Education and Research Hospital, Department of Pediatric Immunology, Antalya, Turkey.
出版信息
J Clin Res Pediatr Endocrinol. 2013;5(1):40-3. doi: 10.4274/Jcrpe.879. Epub 2013 Jul 1.
Abstract
OBJECTIVE
To evaluate the contribution of cytotoxic T-Iymphocyte antigen-4(CTLA-4)+49A/G polymorphism to the susceptibility to type-1 diabetes (T1D) in Turkish children.
METHODS
A case-control study was designed to include 91 Turkish children with T1D and 99 healthy controls. CTLA-4 (+99A/G) gene polymorphism typing was done by PCR amplification followed by restriction fragment length polymorphism method.
RESULTS
The genotype and allele frequencies of the CTLA-4 (+99A/G)polymorphism in patients with T1D were not different from those in the controls (p>0.05). The allele frequency of G was 36.2% in patients with T1D,and 31.8% in controls (p>0.05). Additionally, this polymorphism was not associated with the clinical and laboratory characteristics of the patients with T1D (p>0.05).
CONCLUSIONS
Our case-control study suggests that the CTLA-4 (+99A/G) gene polymorphism is not associated with T1D in the Turkish population.
摘要
目的
评估细胞毒性T淋巴细胞抗原4（CTLA-4）+49A/G多态性对土耳其儿童1型糖尿病（T1D）易感性的影响。
方法
设计一项病例对照研究，纳入91名患T1D的土耳其儿童和99名健康对照。采用聚合酶链反应（PCR）扩增后限制性片段长度多态性方法对CTLA-4（+99A/G）基因多态性进行分型。
结果
T1D患者中CTLA-4（+99A/G）多态性的基因型和等位基因频率与对照组无差异（p>0.05）。T1D患者中G等位基因频率为36.2%，对照组为31.8%（p>0.05）。此外，该多态性与T1D患者的临床和实验室特征无关（p>0.05）。
结论
我们的病例对照研究表明，CTLA-4（+99A/G）基因多态性与土耳其人群的T1D无关。
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