Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Ital J Pediatr. 2009 Apr 30;35(1):10. doi: 10.1186/1824-7288-35-10.
Purpura fulminans (PF) is an ominous cutaneous condition usually associated with meningococcemia. PF in the newborn is rarely reported. We report the case of a female preterm infant with extensive PF due to group B streptococcus (GBS) septicemia. She developed multi-organ system failure despite neonatal intensive care support and succumbed 9 days later. GBS, sensitive to penicillin, was isolated from the blood cultures of the mother and the infant. Invasive early GBS infection is common in the newborn and is empirically treated with prompt institution of intravenous antibiotics. PF associated with GBS is a rare cutaneous sign that must not be missed. Mortality remains high despite aggressive treatment and ICU support.
暴发性紫癜（PF）是一种凶险的皮肤病症，通常与脑膜炎球菌血症相关。新生儿 PF 极为罕见。我们报告了一例因 B 型链球菌（GBS）败血症导致广泛 PF 的女性早产儿病例。尽管新生儿重症监护支持，但患儿仍发展为多器官系统衰竭，并于 9 天后死亡。青霉素敏感的 GBS 从母亲和婴儿的血培养中分离出来。侵袭性早期 GBS 感染在新生儿中很常见，经验性地给予及时的静脉内抗生素治疗。与 GBS 相关的 PF 是一种罕见的皮肤征象，不容忽视。尽管进行了积极的治疗和 ICU 支持，死亡率仍然很高。
