Hon Kam Lun, Chan King Hang, Ko Pak Long, So King Woon, Leung Alexander K C
The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
Case Rep Pediatr. 2017;2017:8418105. doi: 10.1155/2017/8418105. Epub 2017 Oct 1.
We report a neonate who presented with early onset or group B streptococcus (GBS) septicemia within 24 hours of birth. After discharge at day 14, she went on to develop late onset GBS meningitis at 36 days of age. The infant was treated with intravenous antibiotics on both occasions and eventually discharged home with no apparent sequelae. We address issues associated with GBS infection in infancy including the demographics, risk factors, and the risk of late onset GBS meningitis following an early onset GBS infection. The major source of GBS in early onset GBS disease is maternal birth canal GBS colonization. On the other hand, nosocomial cross-infection is an important source of GBS in late onset disease. Penicillin remains the current treatment of choice for GBS infection. Given the rapid onset and progression within hours of birth and lack of an effective solution for preventing late onset GBS, administration of an effective GBS vaccine in pregnancy could provide a sensible and cost-effective solution in all settings.
我们报告了一名新生儿，其在出生后24小时内出现早发型B族链球菌（GBS）败血症。在出生后第14天出院后，她在36日龄时又患上了晚发型GBS脑膜炎。该婴儿在两次发病时均接受了静脉抗生素治疗，最终出院回家，未留下明显后遗症。我们探讨了与婴儿期GBS感染相关的问题，包括人口统计学特征、危险因素以及早发型GBS感染后发生晚发型GBS脑膜炎的风险。早发型GBS疾病中GBS的主要来源是母亲产道GBS定植。另一方面，医院内交叉感染是晚发型疾病中GBS的重要来源。青霉素仍然是目前GBS感染的首选治疗药物。鉴于出生后数小时内发病迅速且进展快，以及缺乏预防晚发型GBS的有效解决方案，在孕期接种有效的GBS疫苗在所有情况下都可能提供一个合理且具有成本效益的解决方案。
