Elayappen Avanikkha, Jain Sunil K, Loeffelholz Michael J, Patel Janak
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.
Department of Pathology, University of Texas Medical Branch, Galveston, Texas.
AJP Rep. 2014 Nov;4(2):e69-72. doi: 10.1055/s-0034-1376186. Epub 2014 Jun 10.
Purpura fulminans (PF) is a skin manifestation due to hemorrhagic infarction caused by intravascular thrombosis secondary to bacterial infections or deficiency of anticoagulants such as protein C and protein S. Neonatal PF is a rare but potentially disabling disorder associated with a high mortality and severe long term morbidity in those who survive.
We report a case of a premature infant who developed extensive PF due to late onset group B streptococcus sepsis. Despite early identification and initiation of antibiotic therapy in our patient, PF progressed rapidly, leading to autoamputation of fingers and toes and severe brain injury.
In conclusion, our case highlights the severe sequelae of PF due to late onset GBS sepsis in a premature infant.
暴发性紫癜（PF）是一种皮肤表现，由细菌感染或抗凝剂（如蛋白C和蛋白S）缺乏继发的血管内血栓形成导致出血性梗死引起。新生儿PF是一种罕见但可能致残的疾病，与高死亡率以及幸存者严重的长期发病率相关。
我们报告一例早产儿因晚发性B族链球菌败血症发生广泛PF的病例。尽管我们的患者早期得到识别并开始了抗生素治疗，但PF进展迅速，导致手指和脚趾自动截肢以及严重脑损伤。
总之，我们的病例突出了早产儿因晚发性GBS败血症导致PF的严重后遗症。
