Helix-loop-helix genes translocated in lymphoid leukemia.
作者信息
Visvader J, Begley C G
机构信息
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, Victoria, Australia.
出版信息
Trends Biochem Sci. 1991 Sep;16(9):330-3. doi: 10.1016/0968-0004(91)90137-k.
PMID:1949153
Abstract
A new class of DNA-binding proteins with a helix-loop-helix (HLH) structure has recently been described. Many of these transcriptional regulators are known to play a central role in cell-specification and differentiation processes. Four members of the HLH family are now implicated in the development of human lymphoid malignancies as a result of aberrant expression following chromosomal translocation events. This review focuses on two of these family members: SCL and LYL-1.
摘要
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