Gallo Richard L, Nizet Victor
Department of Medicine and Pediatrics, Division of Dermatology, University of California, San Diego and VA Healthcare System, San Diego, CA.
Drug Discov Today Dis Mech. 2008 Jun 1;5(2):145-152. doi: 10.1016/j.ddmec.2008.04.009.
The innate immune system is primarily responsible for prevention of infection of the skin by pathogens, but is also important in control of inflammation. The components of innate immunity are frequently misunderstood based on a historical bias for leukocyte-mediated immune defense. Many participating cell types are often overlooked, in particular epithelial cells that provide an early and critical step to innate immune defense. This review will discuss our epithelial barrier to infection with emphasis on how microbes subvert this system, and human diseases associated with these events.
先天性免疫系统主要负责预防病原体对皮肤的感染,但在控制炎症方面也很重要。基于白细胞介导的免疫防御的历史偏见,先天性免疫的组成部分常常被误解。许多参与的细胞类型经常被忽视,特别是上皮细胞,它们为先天性免疫防御提供了早期且关键的一步。本综述将讨论我们针对感染的上皮屏障,重点是微生物如何破坏该系统以及与这些事件相关的人类疾病。