Buchan Zachary A, Bader Scott J, Montgomery John
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.
Angew Chem Int Ed Engl. 2009;48(26):4840-4. doi: 10.1002/anie.200901666.
Gettin' a little sugar-no alcohol required: A procedure for the direct glycosylation of ketones without a hydroxy intermediate enables the site-selective glycosylation of hydroxyketones at the ketone or the alcohol functionality without the use of protecting groups on the aglycone (see scheme). Site selectivity is controlled by the catalyst structure in hydrosilylation and dehydrogenative silylation reactions with sugar silanes. Bn=benzyl.