糖肽作为糖生物学的多功能工具。

Glycopeptides as versatile tools for glycobiology.

作者信息

Buskas Therese, Ingale Sampat, Boons Geert-Jan

机构信息

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA, USA.

出版信息

Glycobiology. 2006 Aug;16(8):113R-136R. doi: 10.1093/glycob/cwj125. Epub 2006 May 4.

DOI:10.1093/glycob/cwj125

PMID:16675547

Abstract

This review describes the recent advances in the field of glycopeptide and small glycoprotein synthesis. The strategies covered include chemical and chemoenzymatic synthesis, native chemical ligation (NCL), and expressed chemical ligation. The importance of glycopeptide synthesis is exemplified by giving the reader an overview of how versatile and important these well-defined glycopeptides are as tools in glycobiology.

摘要

本综述描述了糖肽和小糖蛋白合成领域的最新进展。所涵盖的策略包括化学合成和化学酶法合成、天然化学连接（NCL）以及表达化学连接。通过向读者概述这些结构明确的糖肽作为糖生物学工具的多功能性和重要性，例证了糖肽合成的重要性。