Quiclet-Sire Béatrice, Revol Guillaume, Zard Samir Z
Laboratoire de Synthèse Organique, CNRS UMR 7652, Département de Chimie, Ecole Polytechnique, 91128 Palaiseau, France.
Org Lett. 2009 Jul 2;11(13):2832-5. doi: 10.1021/ol9010294.
A route to biaryl-3-carboxylate esters involving a radical 1,2-aryl migration has been developed. This strategy hinges on the radical addition of xanthate 2 to olefin 1 causing a 1,2-aryl shift leading to alpha,beta-unsaturated ester 5, which is then converted into biaryl 10 by treatment with DBU under microwave heating.
一种涉及自由基1,2-芳基迁移的制备联芳基-3-羧酸酯的方法已经开发出来。该策略基于黄原酸酯2对烯烃1的自由基加成，引发1,2-芳基迁移，生成α,β-不饱和酯5，然后在微波加热条件下用DBU处理，将其转化为联芳基化合物10。
