Adeniran Adebowale J, Tamboli Pheroze
Arch Pathol Lab Med. 2009 Jun;133(6):987-91. doi: 10.5858/133.6.987.
In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a müllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and patient outcomes remain unclear. Currently, surgery is the treatment of choice. Nephrogenic adenoma is the most important differential diagnostic consideration, followed by metastatic clear cell carcinoma.
在这篇简短的综述中，我们讨论膀胱透明细胞腺癌，这是一种主要影响女性的罕见肿瘤。该肿瘤的组织发生尚不确定；在一些肿瘤中，临床病理和组织学特征提示苗勒氏起源。膀胱透明细胞腺癌由具有丰富透明细胞质的细胞组成，呈实性、腺性或微管囊状排列。这些肿瘤的全细胞角蛋白、细胞角蛋白7和CA 125免疫组化染色呈阳性。患者通常表现为肉眼血尿、排尿困难和分泌物。其自然病史了解甚少，患者的预后仍不明确。目前，手术是首选的治疗方法。肾源性腺瘤是最重要的鉴别诊断考虑因素，其次是转移性透明细胞癌。
