Paredes-Sabja Daniel, Sarker Mahfuzur R
Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, 216 Dryden Hall, Corvallis, OR 97331, USA.
Future Microbiol. 2009 Jun;4(5):519-25. doi: 10.2217/fmb.09.31.
Enterotoxigenic Clostridium perfringens has been recognized as a ubiquitous human pathogen owing to, at least in part, three important characteristics. First, this bacterium undergoes asymmetric cell division or sporulation under nutritionally deprived conditions. Second, during sporulation growth it produces C. perfringens enterotoxin, an important virulence factor for food poisoning and nonfood-borne gastrointestinal diseases in humans. Third, at the final stage of sporulation, sporulating cells lyse to release mature dormant spores, which are resistant to high heat and can survive in the environment for long periods of time. Here, we present an overview of what is currently known about the mechanisms of sporulation, sporulation-regulated C. perfringens enterotoxin synthesis and spore heat resistance and we discuss their impact on the pathogenesis of C. perfringens.
产肠毒素性产气荚膜梭菌已被公认为一种广泛存在的人类病原体，这至少部分归因于三个重要特征。首先，这种细菌在营养匮乏的条件下会进行不对称细胞分裂或形成芽孢。其次，在芽孢形成生长过程中，它会产生产气荚膜梭菌肠毒素，这是导致人类食物中毒和非食源性胃肠道疾病的一种重要毒力因子。第三，在芽孢形成的最后阶段，形成芽孢的细胞会裂解以释放成熟的休眠芽孢，这些芽孢耐高温，可在环境中长时间存活。在此，我们概述了目前已知的芽孢形成机制、芽孢形成调控的产气荚膜梭菌肠毒素合成以及芽孢耐热性，并讨论了它们对产气荚膜梭菌发病机制的影响。
